Giant Cell Tumors of Bone in the E.N.T. Organs: Report of Two Cases in the Frontal Sinus

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Abstract
This is a report on two patients with giant cell tumors of bone located in the frontal sinus. In both patients potential malignancy was suspected. The first patient, female, had a polyostotic form of the disease located in the frontal sinus and acromion. The second patient, male, had the cystic form of tumor in the frontal sinus, with involvement of the ethmoidal labyrinth. The laboratory findings of both patients showed no abnormalities. Both patients were treated surgically and showed no recurrence 2 years after operation. The authors discuss the cases collected from the otolaryngological literature with occurrence in various organs of the E.N.T. region. They are very rare in this area and there is therefore little experience of their diagnosis and treatment. As the diagnosis of this disease in the E.N.T. organs is made mostly after the operation, the postoperative biopsy is of utmost importance as to the prognosis. Long-term observation of patients is imperative. Primary irradiation is not recommended.

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