IMMUNOHISTOCHEMICAL LOCALIZATION OF S-100 PROTEIN AND PERIPHERAL-NERVE MYELIN PROTEINS (P2-PROTEIN, P0-PROTEIN) IN GRANULAR-CELL TUMORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 112  (2) , 139-146
Abstract
The presence and distribution of nervous-system-specific protein (S-100 protein), peripheral nerve myelin proteins (P2 protein and P0 protein) that have not been given any attention in the field of tumor pathology, and striated muscle-related proteins (myoglobin and myosin) were studied in 18 [human] cases of granular cell tumor by the peroxidase-antiperoxidase method. The granular cells of all cases were negatively stained with antistriated-muscle-related protein antiserums. They were positively stained with anti-S-100 protein, P2 protein and P0 protein antisera. The distribution of P2 protein and P0 protein corresponded with that of characteristic PAS[periodic acid-Schiff]-positive granules on serial sections. Angular bodies in the interstitial cells were also positively stained with anti-P2 protein antiserum and anti-P0 protein antiserum. The granular cell tumor is possibly derived from Schwann cells. Myelin proteins may be major core proteins of the characteristic granules and angular bodies of interstital cells. The biologic significance of these results in relation to myelinogenesis is also discussed.