Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication
- 1 June 1989
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 9 (3) , 155-158
- https://doi.org/10.1002/jat.2550090304
Abstract
The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.Keywords
This publication has 17 references indexed in Scilit:
- Erythrocyte and plasma lipid peroxides in chronic alcoholic patientsDrug and Alcohol Dependence, 1986
- Inhibition of ethanol- and aldehyde-induced release of ethane from isolated perfused rat liver by pargyline and disulfiramPharmacology Biochemistry and Behavior, 1983
- Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawalBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
- Effect of an Acute Dose of Ethanol on Lipid Peroxidation and on the Activity of Microsomal Glutathione S‐Transferase in Rat LiverActa Pharmacologica et Toxicologica, 1983
- Depressed hepatic glutathione and increased diene conjugates in alcoholic liver diseaseDigestive Diseases and Sciences, 1983
- Pharmacology of acetaldehydeCanadian Journal of Physiology and Pharmacology, 1983
- Liver lipoperoxidative pressure and glutathione status following acetaldehyde and aliphatic alcohols pretreatments in the ratBiochemical and Biophysical Research Communications, 1982
- Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relation to its lipoperoxidative capacity in the ratFEBS Letters, 1980
- Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry, 1979
- The effects of ethanol on hepatic lipid peroxidation and on the activities of glutathione reductase and peroxidaseFEBS Letters, 1973