SOLID PHASE SYNTHESIS AND SOME HORMONAL ACTIVITIES OF 1-DEAMINO-4-L-VALINE-8-D-HOMOLYSINE-AND 1-DEAMINO-4-L-VALINE-8-D-HOMOARGININE-VASOPRESSIN
- 1 September 1977
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 10 (3) , 240-244
- https://doi.org/10.1111/j.1399-3011.1977.tb01740.x
Abstract
1-Deamino-4-L-valine-8-DL-homolysine-vasopressin and protected 1-deamino-4-L-valine-8-D-lysine-vasopressin were synthesized by the solid phase method and were then converted into the title compounds (dVDHLVP and dVDHAVP) by tryptic digestion and e-guanidination, respectively. The new hormone analogues exhibit only moderate antidiuretic potency, dVDHLVP 21 units/mg and dVDHA VP 31 units/mg, but since they are essentially devoid of pressor activity (0.01 units/mg) the A/P ratios are very high. In fact, dVDHLVP is the most specific antidiuretic agent in the lysine series known so far.Keywords
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