Further Mutational Studies on the PAS Resistance of Mycobacterium tuberculosis var. hominis

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Abstract
Mutational studies on the PAS (sodium p-amino-salicylate) resistance of Mycobacterium tuberculosis var hominis, strain H37 RV have been carried out. It has been assumed that 1 type of population structure of clones with relation to drug resistance corresponds to one genotype. Clones derived from single colonies obtained on different PAS concentrations produced 3 types of population structure. The 1st type is similar to the parent strain not previously exposed to the drug; resistance level is 0.2 [mu]g PAS/ml. The second and third types differ from the parent strain, their levels of resistance being 3 and 1000 [mu]g PAS/ml, respectively. Neither intermediate population structures nor intermediate levels of resistance were clearly observed. It is concluded that there are only 2 genotypes responsible for PAS resistance, one determining a lower, the other a higher degree of resistance.

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