The In vitro Uptake of 14 C-Praziquantel by Cestodes, Trematodes, and a Nematode
- 1 December 1980
- journal article
- research article
- Published by JSTOR in Journal of Parasitology
- Vol. 66 (6) , 920-925
- https://doi.org/10.2307/3280390
Abstract
14C-praziquantel was taken up rapidly by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. S. mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel through the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.This publication has 9 references indexed in Scilit:
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