Isolation of methylcholanthrene“initiated” C3H/10T1/2 cells by inhibiting neoplastic progression with retinyl acetate
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 3 (3) , 279-285
- https://doi.org/10.1093/carcin/3.3.279
Abstract
12-O-Tetradecanoylphorbol-13-acetate promotion of skin tumors in mice can be inhibited by topical application of either the phospholipase A2 inhibitor dibromoacetophenone or the cyclooxygenase-lipoxygenase inhibitors 5,8,11,14-eicosatetrayonic acid or 1-phenyl-3-pyrazolidinone. The phospholipase A2 inhibitors in particular appear to be among the most potent inhibitors of skin tumor promotion known. These results support the hypothesis that at least some of the products of arachidonic acid transformation are essential for tumor promotion.This publication has 14 references indexed in Scilit:
- MODULATION OF CELLULAR INTERACTIONS BETWEEN C3H-1OT1/2 CELLS AND THEIR TRANSFORMED COUNTERPARTS BY PHOSPHODIESTERASE INHIBITORS1979
- EFFECT OF THE DURATION OF RETINYL ACETATE FEEDING ON INHIBITION OF 1-METHYL-1-NITROSOUREA-INDUCED MAMMARY CARCINOGENESIS IN THE RAT1979
- N-(4-HYDROXYPHENYL)RETINAMIDE - NEW RETINOID FOR PREVENTION OF BREAST-CANCER IN THE RAT1979
- VITAMIN-A AND LUNG-CANCER1979
- REVERSIBLE INHIBITION BY RETINOIDS OF 3-METHYLCHOLANTHRENE-INDUCED NEOPLASTIC TRANSFORMATION IN C3H-10T1/2 CLONE 8 CELLS1979
- CELL DENSITY DEPENDENCE OF FOCUS FORMATION IN C3H-10T1-2 TRANSFORMATION ASSAY1977
- In Vitro Transformation of Normal Cells to Tumor Cells by Carcinogenic Hydrocarbons2JNCI Journal of the National Cancer Institute, 1965
- Some Biological Aspects of Skin Carcinogenesis*Published by S. Karger AG ,1964
- THE INITIATING AND PROMOTING ELEMENTS IN TUMOR PRODUCTIONThe Journal of Experimental Medicine, 1944
- A developing factor in experimental blastogenesisThe Journal of Pathology and Bacteriology, 1944