Some Physiologic Responses to 5-Hydroxytryptamine Creatinine Sulfate

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Abstract
Physiologic studies are reported with a new synthetic compound, 5-hydroxytryptamine creatinine sulfate (SCS), which is probably identical to a component previously crystallized from serum by others and called serotonin creatinine sulfate. In peripheral wound expts. with normal animals SCS admd. intraven. produced immediate hemostasis. A similar response was obtained with heparinized rats and a group of eviscerated rats. SCS had no influence on in vitro blood clotting systems. Hemostasis caused by SCS was of limited duration but could be prolonged by reinjn. Vasoconstriction was seen in the vascular bed of the rat mesoappendix after application of SCS. These expts. indicated that the role of SCS in hemostasis must be that of a vasoconstrictor. The effective hemostatic dose of SCS was near the fatal dose for animals under any 1 of several anesthetics; unanesthetized animals tolerated larger amts. SCS was not anti-histaminic in the guinea pig; the toxicity of the 2 drugs was additive. Hyperglycemia followed injn. of SCS into rabbits, rats and adrenal-demedullated rats. SCS given to pregnant rats did not act as an ocytocic agent but 80% of the pups born at term were dead.