Carbamazepine—A double‐blind comparison with phenytoin

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Abstract
In a double-blind crossover study, carbamazepine and phenytoin were compared as single anticonvulsants in 47 patients with focal and major generalized seizures. Each drug provided superior seizure control in about half the patients but significantly fewer patients had objective side effects while taking carbamazepine. Neuropsychologic testing showed improved performance in cognitive function and emotional status of patients while on carbamazepine. No hematotoxic complications arose but vigilant follow-up is advised. Mean serum level of carbamazepine was 9.3 .mu.g/ml with a suggested therapeutic range of 8-12 .mu.g/ml, reached by eventual doses of 16-20 mg/kg. Carbamazepine offers an independent choice of improved seizure control with a possibility of fewer side effects.

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