Diastereoselective Addition of Allylzinc Bromide to Imines Derived from (R)-Phenylglycine Amide
- 1 November 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (24) , 3943-3946
- https://doi.org/10.1021/ol016840f
Abstract
The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric purity are obtained from the adducts in three steps on removal of the chiral auxiliary by means of a nonreductive protocol. Removal of the auxiliary by hydrogenation leads to the saturated amines, also in high enantiomeric purity.Keywords
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