DISTRIBUTION OF α‐ AND β‐ADRENOCEPTORS IN HUMAN URINARY BLADDER

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Abstract
1 The distribution of α- and β-adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. 2 Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. 3 Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. 4 Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. 5 It is concluded that the bladder neck contains mainly α-receptors and the detrusor mainly β-receptors but both regions possess both types of adrenoceptor.