Mathematical Modelling of the Primary and Secondary Drying Stages of Bulk Solution Freeze-Drying in Trays: Parameter Estimation and Model Discrimination by Comparison of Theoretical Results With Experimental Data
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Drying Technology
- Vol. 15 (3-4) , 791-810
- https://doi.org/10.1080/07373939708917262
Abstract
A mathematical model was constructed and solved in order to describe quantitatively the dynamic behavior of the primary and secondary drying stages of the freeze-drying of pharmaceuticals in trays. The theoretical results were compared with the experimental data of the freeze-drying of skim milk, and the agreement between the experimental data and the theoretical results is good. Detailed model calculations have indicated that the contribution of the removal of hound (unfrozen) water to the total mass flux of the water removed during primary drying, is not significant. For this reason, it was found that one could notKeywords
This publication has 8 references indexed in Scilit:
- Research and Development Needs and Opportunities in Freeze DryingDrying Technology, 1996
- Freeze-Drying of Pharmaceutical Crystalline and Amorphous Solutes in Vials: Dynamic Multi-Dimensional Models of the Primary and Secondary Drying Stages and Qualitative Features of the Moving InterfaceDrying Technology, 1995
- A theory for the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes: comparison between experimental data and theorySeparations Technology, 1994
- Apparent yield stress estimation in xanthan gum solutions and fermentation broths using a low-cost viscometerThe Chemical Engineering Journal, 1991
- DUSTY-GAS PARAMETERS OF ACTIVATED CARBON ABSORBENT PARTICLESChemical Engineering Communications, 1987
- An analysis of the lyophilization process using a sorption‐sublimation model and various operational policiesAIChE Journal, 1985
- Optimal control of a freeze dryer—I Theoretical development and quasi steady state analysisChemical Engineering Science, 1979
- Technical note: Determination of moisture profiles from temperature measurements during freeze dryingInternational Journal of Food Science & Technology, 1974