Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein–Barr virus
- 1 November 2003
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 84 (11) , 2987-2992
- https://doi.org/10.1099/vir.0.19252-0
Abstract
Epstein–Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-β-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.Keywords
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