Successful treatment of severe refractory aplastic anemia with 3‐β etiocholanolone and nandrolone decanoate

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Abstract
A patient with aplastic anemia, who had been unresponsive to androgens, antithymocyte globulin, high‐dose methylprednisolone, and cyclosporine, responded to treatment with 3‐β‐etiocholanolone, nandrolone decanoate, and prednisolone acetate. Six months following intiation of therapy, she became red cell and platelet transfusion independent with neutrophils persistently over 1,000/μl. A sustained partial remission has persisted for over 2 years. This observation suggests that a combined hematostimulatory approach may be of benefit, even in patients with long‐standing refractory aplasia.