Cytotoxic Antibody in Normal Human Serums Reactive with Tumor Cells from Acute Lymphocytic Leukemia
- 20 October 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4058) , 304-306
- https://doi.org/10.1126/science.178.4058.304
Abstract
Serums showing complement-dependent cytotoxic reactions to acute lymphocytic leukemia cells were detected in three normal unimmunized subjects. These serums were reactive with tumor cells from 514 (514 tested) acute lymphocytic leukemia patients, and three (12 tested) patients with acute myelocytic leukemia; they did not react with tumor cells from patients with acute monocytic leukemia (two tested), with chronic lymphocytic leukemia (two tested) or with leukolymphosarcoma (two tested); nor did they react with normal lymphocytes from 52 different donors. These reactive serums appear to recognize antigens primarily associated with acute lymphocytic leukemia.Keywords
This publication has 5 references indexed in Scilit:
- Human Sarcomas Contain RNA Related to the RNA of a Mouse Leukemia VirusScience, 1972
- Detection of an Antigen Associated with Acute LeukemiaScience, 1971
- RNA Dependent DNA Polymerase of Human Acute Leukaemic CellsNature, 1970
- A SIMPLE MICRO CYTOTOXICITY TESTTransplantation, 1969
- Cytotoxic Antibody in Burkitt's Tumor and Normal Human Serum Reactive with Cultures of Lymphoid CellsExperimental Biology and Medicine, 1968