Evaluation of Limonoids Against the Murine P388 Lymphocytic Leukemia Cell Line
- 1 May 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 46 (3) , 379-390
- https://doi.org/10.1021/np50027a015
Abstract
A structure/activity study of selected limonoids [38] from 2 plant families (Meliaceae and Rutaceae) of the Rutales against the murine P-388 lymphocytic leukemia system [PS] was undertaken. The presence of both a 19 .fwdarw. 28 lactol and a 14,15.beta.-epoxide group was found especially important for pronounced inhibition of the PS in vitro cell line. Substitution of an A-ring .alpha.,.beta.-unsaturated ketone (3-oxo-1-ene) for the lactol led to diminished activity, while reduction of the olefin caused complete loss of activity. At the dose levels employed, even very good PS in vitro inhibition was not translated into PS in vivo antineoplastic effects.This publication has 10 references indexed in Scilit:
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