Über den Zusammenhang zwischen Walker-Tumorwachstum und verminderter d-Aminosäureoxydase-Wirksamkeit

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Abstract
White rats were inoculated with fresh Walker tumor suspensions. After 2-4 weeks, the tumors, which had grown quite large, were removed under ether anesthesia. After 10-12 days, the rats were killed and d-amino acid oxidase extracts of their livers and of livers of normal rats prepared. The potency of the extracts was detd. at 36.4[degree] in the Warburg apparatus. The reaction mixture contained extract corresponding to 0.4 g. liver, 5 . 10-4 mol. (44.5 mg.) d,l-alanine in 1 cc. M/2 phosphate (pH 8.0), and 5[gamma] Ba salt of alloxazine-adenine-dinucleotide. The O2 uptake of liver extract of the rats which had had tumors was the same as that of the liver extract of the normal rats. It was concluded that the conc. of d-amino acid oxidase in the livers of the two groups was the same. The livers of rats in which the tumors were not completely removed showed a decreased d-amino acid oxidase content. There was no decrease in the liver oxidase activity of rats recovering from extensive burn injuries. In the body, the d-amino acid oxidase appears to convert the d-amino acids into the natural l-amino acids.

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