Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
- 9 September 2007
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 10 (10) , 1238-1240
- https://doi.org/10.1038/nn1974
Abstract
We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.Keywords
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