Effect of an Intravenous Infusion of Aminoacids (Aminoplex 14) on Gastric Secretion in Healthy Subjects and Patients with Duodenal Ulcers

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Abstract
The effect of an i.v. infusion of an amino acid solution (Aminoplex 14) on gastric secretion is compared in healthy subjects and in duodenal ulcer patients. The acid secretory response was twice as high in duodenal ulcer patients than in normal subjects, 60 min after starting the infusion. Serum gastrin levels, although initially higher in duodenal ulcer patients, showed no augmentation throughout the infusion. Blood glucose, serum osmolality and PCV [packed cell volume] estimations did not alter significantly. Serum amino acid levels showed a pronounced rise, doubling basal values, and tended to parallel the increase in acid output. Cimetidine, administered orally, suppressed the acid secretory response to i.v. amino acid. The marked stimulation in acid secretion following amino acid infusion in duodenal ulcer patients was not elicted after truncal or highly selective vagotomy.