Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs

Publisher Website
Google Scholar
Abstract
The effect of 2 known inhibitors of prostaglandin [PG] synthesis, indomethacin and aspirin, on blood flow was studied in 6 Heidenhain pouch and 3 antral pouch dogs. The unstimulated gastric mucosa was bathed with 0.15 M HCl and clearance of [14C]-aminopyrine was used as an index of changes in mucosal blood flow. [14C]aminopyrine clearance was measured during three 15 min predrug periods and five 15 min post drug periods. Indomethacin (10 mg/kg) aspirin (100 mg/kg) or 0.15 M NaCl were given i.v. a bolus. Indomethacin reduced mucosal blood flow in the Heidenhain pouch 52% (P < 0.05). Aspirin reduced Heidenhain pouch mucosal blood flow 31% (P < 0.05). Indomethacin caused no significant change in electrical potential difference or in net flux of H+ or Na+ in Heidenhain pouches. Indomethacin (10 mg/kg i.v.) produced no change in mean arterial pressure. Indomethacin and aspirin reduced unstimulated gastric mucosal blood flow; apparently, endogenous PG may contribute to its maintenance.