Some Effects of 400-Mev Protons on Primates

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Abstract
Primates were given spaced doses of 400-Mev protons. From the mortality data an LD50(30) of 585 [plus or minus] 33 (S.E.) rads was calculated. Hematological measurements, LDH [Lactic dehydrogenase] and SGOT [serum glutamic oxalacetic transaminase] concentrations, Fe59 ferrokinetics, and histopathological findings indicate that the effects produced by the protons are virtually identical to those produced by equivalent doses of 2-Mev X-rays. The only differences in response were clinical; relatively more intense gastrointestinal and hemorrhagic signs occurred after proton irradiation than after similar doses of the X-rays.