Ascorbic Acid: A Culture Requirement for Colony Formation by Mouse Plasmacytoma Cells
- 12 November 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4010) , 720-722
- https://doi.org/10.1126/science.174.4010.720
Abstract
Plasmacytoma stem cells explanted from mice formed colonies in culture only in the presence of L-ascorbic acid; this vitamin was not needed for the formation of granulocytic colonies. Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively. Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.Keywords
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