Streptokinase Resistance in Medical Patients in Oslo

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Abstract
The streptokinase titrated initial [antibody] dose (TID) was estimated in 312 patients consecutively admitted to a medical department in Oslo, Norway; 93% had a TID below 250,000 IU, 97% below 425,000 IU and 98.5% below 650,000 IU. No differences were found between the sexes. The highest values were found in patients 50-60 yr old. Otherwise, no differences were found between different age groups from 10-90 yr old. Two patients with extremely high TID values were both anamnestically prone to streptococcal infections. The standard initial dose of 250,000 IU of streptokinase [for fibrinolytic therapy of thromboembolic diseases] is apparently sufficient for most of these patients. Pre-treatment test for TID is recommended only when recent streptococcal infections are suspected.