Sulfonamide Susceptibility of Stock Strains of Dysentery Bacilli and of Strains from Recent Epidemics

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Abstract
A method of testing the sensitivity of dysentery bacilli to the bacteriostatic action of Na sulfadiazine is described. The method involves the use of a medium which is essentially free of sulfonamide inhibitors. Of 219 strains tested, inhibition of growth of 202 strains was caused by a drug conc. of [image]/- 20,000 or less, while growth of the remaining 17 strains was not completely inhibited by a conc. of M/125. Among the susceptible strains were representatives of each of the well established vars. of Shigella. The resistant strains included representatives of S. paradysenteriae (Flexner types W, Z and VZ) and S. sonnei. Many of the resistant strains were isolated from patients who failed to respond to treatment with sulf onamides. The results serve to emphasize a potential difficulty in the chemotherapy of dysentery.

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