Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit

1 December 1977

journal article
Published by Springer Nature in Cellular and Molecular Life Sciences

Vol. 33 (12) , 1626-1627
https://doi.org/10.1007/bf01934038

Abstract

Hyperthermia induced by arachidonic acid in rabbit was attenuated by phenoxybenzamine, cyproheptadine and indomethacin. The reduction in arachidonic acid hyperthermia, after 6-OH-DA and the failure of PCPA to reduce this rise, indicates the involvement of noradrenaline in arachidonic acid hyperthermia.

Keywords

This publication has 12 references indexed in Scilit:

The thermoregulatory effects of prostaglandin E 1 when infused into a lateral cerebral ventricle of the Welsh Mountain sheep at different ambient temperatures.
1973
The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins
British Journal of Pharmacology, 1972
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs
British Journal of Pharmacology, 1972
Actions of 5-hydroxytryptamine and 5-hydroxytryptophan injected by various routes on the rectal temperature of the rabbit
Neuropharmacology, 1972
Further studies on prostaglandin E₁ fever in cats
The Journal of Physiology, 1971
Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits
The Journal of Physiology, 1971
Fever produced by prostaglandin E₁
The Journal of Physiology, 1971
The hyperpolarization of frog skeletal muscle fibres induced by removing potassium from the bathing medium
The Journal of Physiology, 1971
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
Nature New Biology, 1971
A possible role for prostaglandin E1 as a modulator for temperature regulation in the central nervous system of the cat.
1970