EFFECT OF THYROXINE AND THIOURACIL ON THE RATE OF PHOSPHOLIPID TURNOVER IN THE LIVER OF THE RAT

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Abstract
Data concerning the concn. and specific activity of the liver and plasma in organic phosphates and phospholipids were obtained from adult rats at intervals after the injn. of dibasic sodium phosphate P32 Because their specified activities have a constant relationship over a wide var. of exptl. conditions, the specific activity of the liver inorganic phosphates appears to be identical with that of the immediate phosphate precursor of the phospholipids of the liver. Calculations based on this assumption indicate that the rate pf phospholipid turnover in the liver is increased in rats which have received thyroxine and decreased in rats which have been treated with thiouracil. The rate of turnover of the phospholipids of the plasma also appears to be greater than normal in thyroxine-treated rats and less than normal in those receiving thiouracil. The rate of phospholipid turnover in the liver of young rats is essentially the same as that of mature rats but, 18428-18434 ANIMAL PHYSIOLOGY - REPRODUCTION, LACTATION [Vol. 23] 1866 since the relative size of the liver is greater in young rats, more phospholipid is formed in proportion to body wt. than in the adult.

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