Local Tissue Effects Of Surface-Applied Ent Drugs

Publisher Website
Google Scholar
Abstract
Local tissue effects caused by a selected group of topically applied ENT-drugs are analysed. By means of a testing system consisting of vital microscopy, infrared thermography and microangiography applied to hamsters and rabbits, an evaluation of the varying degree of tissue injury is made. According to the degree of tissue damage the tested substances could be graded in three groups (I—III). The drugs belonging to group I show fairly little microcirculatory disturbance, while those belonging to group III cause tissue necrosis. Our conclusion is that topically applied drugs should be used with caution, especially on previously injured tissues.