Anti‐anginal arylalkylamines and sodium channels: [3H]‐batrachotoxinin‐A 20‐α‐benzoate and [3H]‐tetracaine binding
Open Access
- 1 December 1986
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 89 (4) , 641-646
- https://doi.org/10.1111/j.1476-5381.1986.tb11168.x
Abstract
1 [3H]-batrachotoxinin-A 20-α-benzoate ([3H]-BTX-B) and [3H]-tetracaine are useful ligands for the study of sodium channels. 2 Inhibition of their binding by various anti-anginal drugs was tested on a rat synaptosomal preparation and on a heart membrane preparation. 3 Diphenylalkylamines and structurally related drugs inhibited [3H]-BTX-B binding in both the synaptosomal preparation and heart membrane preparation. They were almost inactive on [3H]-tetracaine binding. 4 These results suggest that activity of arylalkylamines could be mediated by an interaction on the sodium channel.This publication has 16 references indexed in Scilit:
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