STUDIES IN SERUM ELECTROLYTES. XV. THE CALCIUM-BINDING PROPERTY OF THE SERUM PROTEINS (MULTIPLE MYELOMA, LYMPHOGRANULOMA VENEREUM AND SARCOIDOSIS)

Open Access
Publisher Website
Google Scholar
Abstract
The Ca-binding property of serum albumin and globulin obtained from normal subjects was estimated. Approx. the same amt. of Ca is bound by both albumin and globulin, the avg. being 0.84 mg. of Ca/g. of protein. In diseases characterized by abnormality of the serum proteins, the Ca-binding property of albumin may increase, in some cases to as much as 6 times the normal value. The Ca-binding property of globulin in such diseases varies from the normal, and the direction of variation appears to depend upon the predominating electro-phoretic globulin fraction present. One or more of several mechanisms appear to be responsible for the hypercalcemia frequently observed in multiple myeloma. These include increased Ca-binding property of the serum albumin, increased concn. of serum globulin and increased concn. of diffusible Ca.