Hereditary Deficiencies of Clotting Factors VII and X Associated with Carotid-Body Tumors

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Abstract
AN elevated prothrombin time as determined by the Quick1 procedure may be due to many abnormalities, including deficiency of factors I (fibrinogen), II (prothrombin), V (achéal-globulin), VII (proconvertin) or X (Stuart). When acquired, these defects arise from hepatic disease, vitamin K deficiency or coumarin therapy. They may also be congenital or inherited.The present investigation was initiated by the incidental preoperative finding of a prolonged Quick prothrombin time in a woman with a carotid-body tumor. The demonstration of a similar clotting abnormality and tumors in a number of the patient's relatives led to a detailed study of all available members . . .