Long-term Effects of Renin-Angiotensin System–Blocking Therapy and a Low Blood Pressure Goal on Progression of Hypertensive Chronic Kidney Disease in African Americans

Open Access
Publisher Website
Google Scholar
Abstract
Hypertensive chronic kidney disease (CKD) is a major public health problem in the United States, especially among African Americans. An estimated 4.5 million Americans have hypertensive CKD, and another 110 000 persons have end-stage renal disease (ESRD) attributed to hypertension.1 According to the US Renal Data System,2 37% of ESRD cases in African Americans can be attributed to hypertension, whereas the corresponding figure in persons of white race/ethnicity is 19%. In studies3,4 conducted before renin-angiotensin system (RAS)–blocking therapy, African Americans with hypertensive CKD experienced continued CKD progression compared with persons of white race/ethnicity, who experienced little or no progression while receiving antihypertensive drug therapy.