ALLELIC ASSOCIATIONS OF MULTIPLE RFLPS OF THE GENE ENCODING COMPLEMENT PROTEIN C2
- 1 May 1990
- journal article
- research article
- Vol. 46 (5) , 956-962
Abstract
The gene for second component of complement, C2, maps within the class III region of the major histocompatibility complex (MHC). Many human diseases have been reported to be associated with MHC alleles, haplotypes, or extended haplotypes, but in most cases additional polymorphic markers are needed for the eventual localization of the genes responsible for these diseases. In this study, nine C2 haplotypes for four restriction-site polymorphisms, detected by SstI, BamHI, and TaqI, were defined among 43 unrelated individuals. Two of these polymorphisms are multiallelic and map near the 5'' end of the C2 gene. The extensive allelic variation of the C2 gene may prove of value in studies of diseases associated with the MHC.This publication has 36 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINSAnnual Review of Biochemistry, 1988
- Cell-specific expression of the human complement protein Factor B gene: Evidence for the role of two distinct 5′-flanking elementsCell, 1987
- Hypervariable ‘minisatellite’ regions in human DNANature, 1985
- TheFactor BandC2genesPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984
- A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor BNature, 1984
- Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologueNature, 1983
- Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.BMJ, 1983
- The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogeneCell, 1982
- The 1982 revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1982