HALOGENATED PROGESTERONE DERIVATIVES AS ANTILUTEINIZERS
- 1 December 1957
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 26 (4) , 371-376
- https://doi.org/10.1530/acta.0.0260371
Abstract
When 11[beta]-hydroxyprogesterone (11[beta]-OH-P) was halogenated with fluorine, it acquired a considerable antiluteinizing potency, superior to progesterone and many times greater than that of 19-nor-[alpha]-ethinyletestos-terone. Since 9[alpha]-fluoro-11[beta]-hydroxyprogesterone showed resistance to intra-heptic inactivation, the authors discussed whether it would be of value in studies of antiovulatory action of gestagens in women.Keywords
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