Metabolic Correlates of Ethanol, Acetaldehyde, Acetate and Methanol in Humans and Animals

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Abstract
The consensus of opinion is that the immediate causes of alcoholism stem mostly from psychological or sociological factors. However, we have little firm knowledge why some people use alcohol excessively; nor do we know much about why some persons are more sensitive or more tolerant to alcohol’s effects than are others.It is well known, however, that ethyl alcohol has important toxic effects on the human organism. The familiar changes in behavior observed during alcohol intoxication and during the alcohol withdrawal period are reflections of some biochemical and/or biophysical changes in the central nervous system and are related to the concentrations of ethanol in body fluids and in the brain.