Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 1 (3) , 253-257
- https://doi.org/10.3109/02652048409049364
Abstract
The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50s of PBC and PHC nanoparticles towards hepatocytes were 0.4mg/2 × 106 cells and >1 mg/2 × 106 cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.Keywords
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