Pagetoid malignant melanoma and lentigo maligna melanoma of toe
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 262 (3) , 275-283
- https://doi.org/10.1007/bf00447364
Abstract
Two cases of malignant melanoma on the toe of middle-aged women were examined chiefly by the fluorescence method of Falck and Hillarp. In one of the patients, histopathology of the pigmented tumor on the left middle toe was a Pagetoid (superficial spreading) melanoma in situ, and the subungual granulomatous lesion on the right great toe in the other patient was a lentigo maligna melanoma. On fluorescence microscopy, characteristic findings of the pigment cells lying in the epidermis of both types may be summarized as follows: In the Pagetoid melanoma, the melanoma cells are ovoid, lack dendritic processes, and emit specific yellow fluorescence. In the lentigo maligna melanoma, the pigment cells clearly show dendritic processes, and emit specific green fluorescence. Maligne Melanome von 2 Patienten wurden fluorescenzmikroskopisch mit der Methode von Falck und Hillarp untersucht. Das Melanom an der linken mittleren Zehe einer Patientin zeigte histologisch eine Form von «Pagetoidem Melanom» in situ. Dagegen wies das, welches am subungualen Bereich der rechten großen Zehe bei einer anderen Patientin in Form eines granulomatösen Herdes gefunden wurde, ein «Lentigo malignes Melanom» auf. Fluorescenzmikroskopisch zeigten die Melanomzellen im ersteren Fall die ovoide Gestalt ohne dendritische Fortsätze, und fluorescierten charakteristisch gelb, während diejenigen im letzteren Fall deutlich dendritische Fortsätze und eine charakteristisch grüne Fluorescenz zeigten.This publication has 14 references indexed in Scilit:
- Focus on MelanomaThe Journal of Dermatologic Surgery and Oncology, 1976
- Melanin-producing dendritic cells and histogenesis of malignant melanomaArchives of Dermatological Research, 1976
- Mechanism of recurrence of pigmented nevi following dermabrasionActa Dermato-Venereologica, 1975
- Fluorescence histochemical and microfluorometrical investigations of pigmentary tumors of the skinArchives of Dermatological Research, 1975
- Dopa and 5-S-cysteinyldopa in malignant melanoma in Ugandan AfricansActa Dermato-Venereologica, 1974
- Lentigo Maligna of the FingertipArchives of Dermatology, 1973
- Cysteinyl dopa in human malignant melanomaActa Dermato-Venereologica, 1972
- The classification of melanoma and its relationship with prognosisPathology, 1970
- Fluorescent Dopa Reaction of Nevi and MelanomasArchives of Dermatology, 1966