Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway
- 15 February 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5558) , 1294-1298
- https://doi.org/10.1126/science.1067765
Abstract
The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements duringCaenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.Keywords
This publication has 30 references indexed in Scilit:
- An E3-like Factor that Promotes SUMO Conjugation to the Yeast SeptinsCell, 2001
- Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeastThe EMBO Journal, 2000
- The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in NeuronsPublished by Elsevier ,2000
- SCF and Cullin/RING H2-Based Ubiquitin LigasesAnnual Review of Cell and Developmental Biology, 1999
- Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin LigaseScience, 1999
- UBIQUITIN-DEPENDENT PROTEIN DEGRADATIONAnnual Review of Genetics, 1996
- A non-muscle myosin required for embryonic polarity in Caenorhabditis elegansNature, 1996
- SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-BoxCell, 1996
- Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component.The Journal of cell biology, 1994
- DNA synthesis and the control of embryonic gene expression in C. elegansCell, 1988