Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
- 1 January 1983
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 141 (1) , 33-39
- https://doi.org/10.1620/tjem.141.33
Abstract
The mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-.beta.-aminoethyl)disulfide].sbd.used as an antiatherogenic drug.sbd.on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4''-phosphopantetheine activated 3 steps of fatty acid oxidation , i.e., acyl-CoA synthetase, carnitine acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.This publication has 7 references indexed in Scilit:
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