Effect of alloxan on rat pancreatic polypeptide (PP) cells

1 March 1977

journal article
research article
Published by Springer Nature in Cell and tissue research

Vol. 178 (3) , 307-312
https://doi.org/10.1007/bf00218695

Abstract

Summary Injection of alloxan caused an almost total disappearance of insulin cells in the rat pancreas. Planimetric analysis revealed a 50 per cent reduction of the mean islet volume. The number of immunoreactive pancreatic polypeptide (PP) cells per sectioned islet was significantly increased, and the PP cell volume per islet doubled. Assuming an unchanged number of islets, the results indicate an increase in total PP cell mass following alloxan administration.

Keywords

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