Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.
- 1 April 1976
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (4) , 1338-1342
- https://doi.org/10.1073/pnas.73.4.1338
Abstract
Insulin-, glucagon-, and somatostatin-contianing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin- and glucagon-containing cells were significantly increased in the islets of juvenile-type human diabetics and of streptozotocin diabetic rats.Keywords
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