Effect of Mineral Oil on Intestinal Absorption of Cholesterol in the Rat

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Abstract
Addition of light mineral oil (USP) at a level of 6% of the dry weight of the diet in rats increased the fecal excretion of endogenous cholesterol by 39% when there was no cholesterol in the diet and increased the total excretion of cholesterol by 30% when cholesterol was added to the diet. It is probable that most of the increased excretion is due to the solubility of cholesterol in the mineral oil (1.1% at 37oC), though laxation is also probably concerned to some extent.

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