PARTITION HYPOTHESIS FOR INTESTINAL ABSORPTION OF FAT

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Abstract
The thoracic duct of dogs was cannulated and mineral oil in various emulsions ranging in particle size from 200 to 0.5[mu] and less was introduced into the alimentary tract. No evidence was obtained indicating that during a period of 15-24 hrs. after its introduction into the intestine the mineral oil, even when finely subdivided (0.2-0.5[mu]), was absorbed in amts. sufficient to cause the lymph in the lacteals to become cloudy or milky or to cause a chemically detectlble increase in non-saponifiable material in thoracic duct lymph or a chemically detectible loss of mineral oil from the lumen of the intestine. The results do not support the partition hypothesis of fat absorption as presented by Frazer; this hypothesis is not supported by the observations of Munk and of Freeman and Ivy, which clearly show that fatty acid may be absorbed in relatively large amts. from the intestine and appear in the chyle as neutral fat in normal and depancreatized dogs.
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