FAT ABSORPTION AND ITS RELATIONSHIP TO FAT METABOLISM

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Abstract
According to the partition hypothesis, neutral fat is absorbed unsplit via the lymphatic system and thoracic duct into the systemic blood and thence to the fat depots, whereas fatty acid passes mainly by the portal vein direct to the liver as cholesteryl esters or soaps or to form phospholipin. Thus the degree of lipolysis may determine how much fat will go to the liver and to the depots. The amt. of cholesterol ingested affects the formation of cholesteryl esters which is also influenced by the bile salts and lipase. The choline content of the diet may affect phospholipin synthesis in the intestinal cells. Both the quantity and quality of the ingested fat affect metabolism and nervous, endocrine, and vitamin factors play their part.