Identification of two new HLA‐A alleles, A*2419 and A*3011, by sequence‐based typing
- 1 February 2002
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 59 (2) , 136-138
- https://doi.org/10.1034/j.1399-0039.2002.590211.x
Abstract
In this report, we describe two new HLA‐A alleles, A*2419 and A* 3011, that were initially recognized by an aberrant serological pattern. Sequence‐based typing revealed sequence differences with other known HLA‐A alleles. Allele A*2419 showed 4 nucleotide differences with A*2404, resulting in 4 amino acid differences at codons 70, 76, 77 and 90. Compared with other A*24 alleles, A*2419 lacks the Bw4 motif, as do A*2404 and A*2428. The A*3011 allele showed 2 mismatches with A*3001, resulting in one amino acid difference at codon 80.Keywords
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