STUDIES OF THE ACUTE RENAL EFFECTS OF HEMOLYZED RED BLOOD CELLS IN DOGS INCLUDING ESTIMATIONS OF RENAL BLOOD FLOW WITH KRYPTON85*

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Abstract
The intra-aortic administration of homologous hemolyzed red blood cells to 12 dogs resulted in acute decreases in urine flow (75%), creatinine clearance (44%), and hippuran clearance (39%). Despite these changes, generalized decreases in renal blood flow measured by a gas diffusion technique using krypton85 did not occur. Consistent changes in renal arteriovenous oxygen difference and the renal extraction of hippuran, creatinine, and para-aminohippurate were absent. In 9 animals, decreases in urine flow were associated with increases in urine/plasma creatinine and osmola-lity. In 3 experiments, oliguria was assoicated with decreased urine/ plasma creatinine and osmolality and decreased renal extraction of hippuran and creatinine. It is concluded that the administration of hemolyzed red blood cells may produce acute alterations in renal function that are unrelated to generalized renal ischemia, hypoxemia, or the occurrence of gross intrarenal shunts. The changes appear to be secondary to intratubular obstruction and concomitant toxic tubular damage.