In-vitro activity of Sch 29482 in comparison with other oral antibiotics

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Abstract
The in-vitro activity of Sch 29482 (SCH) was compared with those of N-formimidoyi thienamycin, moxalactam, and seven oral antibiotics against skin and soft-tissue, respiratory, and gastro-intestinal tract pathogens. Ninety per cent of methicillinsusceptible strains of Staphylococcus aureus and streptococci of groups A, B, C and G were inhibited by SCH concentrations ≤ 0.125 mg/l. The drug was also highly active against Listeria monocytogenes, Pasteurella multocida and Campylobacter fetus ssp. jejuni . N-Formimidoyl thienamycin was the most active agent tested against penicillin-resistant pneumococci and viridans streptococci, but both moxalactam and SCH were superior against Haemophilus influenzae . Susceptibilities of Staphylococcus epidermidis and methicillin-resistant Staph. aureus varied over a wide range.