Experimental evaluation of a pulse contour method for calculation of cardiac output

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Abstract
A method of estimating cardiac output which depends on the analysis of a single propagated pressure wave and the relationship between pressure change and velocity change: Δp = ρc0 Δv, has been evaluated experimentally in 84 almost simultaneous comparisons with dye dilution method measurements and 22 almost simultaneous comparisons with direct Fick measurements. A deviation of 13.4 ± 22.9% between the dye and pulse contour measurements was observed. In comparison with direct Fick measurements, the deviation was 19.1 ± 33.0%. The ability of this pulse contour method to follow changes in cardiac output was better than its ability to estimate absolute output, as indicated by these deviations. The usefulness of this pulse contour technique in estimating cardiac output in clinical and laboratory situations, with a beat-to-beat indication of changes in output, is discussed. In general, this method appears to have a useful degree of accuracy and offers a relatively simple approach to an important problem.

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