Receptor-Dependent Coronavirus Infection of Dendritic Cells
Open Access
- 15 May 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (10) , 5486-5490
- https://doi.org/10.1128/jvi.78.10.5486-5490.2004
Abstract
In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.Keywords
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