ANTIBODY-DEPENDENT CELL-MEDIATED EFFECTS IN BANCROFTIAN FILARIASIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 43  (1) , 117-123
Abstract
The nature of Ig and effector cells involved in the antibody-dependent cell-mediated adhesion and cytotoxicity to Wuchereria bancrofti larvae was investigated. Human neutrophils and eosinophils purified from peripheral blood by metrizamide gradients readily adhered to the parasites in presence of IgG fraction of sera from majority of elephantiasis cases with amicrofilaremia and many of the endemic normals. The cells from normal, microfilariae carriers and elephantiasis cases were equally effective in the adhesion reaction. While the adhered neutrophils killed the larvae, eosinophils were ineffective in this respect. DEC [diethylcholine] treatment of elephantiasis cases results in a significant reduction in the ability of their sera to promote cellular adhesion.