Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Top Cited Papers
- 20 June 2004
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 7 (7) , 695-696
- https://doi.org/10.1038/nn1270
Abstract
The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.Keywords
This publication has 13 references indexed in Scilit:
- Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot TrackingScience, 2003
- AMPA Receptor Trafficking at Excitatory SynapsesNeuron, 2003
- Direct imaging of lateral movements of AMPA receptors inside synapsesThe EMBO Journal, 2003
- The role of receptor diffusion in the organization of the postsynaptic membraneNature Reviews Neuroscience, 2003
- Regulation of AMPA receptor lateral movementsNature, 2002
- Mobile NMDA Receptors at Hippocampal SynapsesNeuron, 2002
- Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase IIJournal of Neuroscience, 2002
- Role of ampa receptor endocytosis in synaptic plasticityNature Reviews Neuroscience, 2001
- Contribution of cytoskeleton to the internalization of AMPA receptorsProceedings of the National Academy of Sciences, 2001
- NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 AreaJournal of Neuroscience, 2000